2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N17247
    Mesembranol 23544-42-5 98%
    Mesembranol ((-)-Mesembranol) is a mesembrine-type alkaloid and serotonin reuptake inhibitor. Mesembranol can be found in Sceletium tortuosum and exhibits phosphodiesterase 4 (PDE4) inhibition. Mesembranol contributes to the psychoactive properties of Sceletium tortuosum. Mesembranol can be used for the research of central nervous system-related conditions.
    Mesembranol
  • HY-N17353
    Vitedoamine A 819861-41-1
    Vitedoamine A is a Phenylnaphthalene-type lignan alkaloid. Vitedoamine A can be isolated from Vitex negundo. Vitedoamine A inhibits the activity of IKKβ with an IC50 value of 39 μM. Vitedoamine A could inhibit the transcriptional activity of NF-κB, and suppress the production of NO and reduce the expressions of inflammatory cytokines (IL-1β, IL-6, and TNF-α). Vitedoamine A inhibits the phosphorylation of IKKα/β and p65, and prevents the degradation of IκBα. Vitedoamine A possesses anti-rheumatoid arthritis capacity.
    Vitedoamine A
  • HY-N17356
    Atalaphyllidine 57959-88-3
    Atalaphyllidine is a natural product. Atalaphyllidine can be isolated from the stem bark of Glycosmis chlorosperma. Atalaphyllidine inhibits DYRK1A kinase activity with an IC50 of 2.2 μM. Atalaphyllidine can be used in the research of neurodegenerative diseases.
    Atalaphyllidine
  • HY-N17394
    Melineurine 85802-28-4
    Melineurine is a reversible mixed-type acetylcholinesterase inhibitor, with an IC50 of 95.3 μM against AChE and an IC50 of 28.0 μM against BChE. Melineurine is applicable to the research of Alzheimer's disease.
    Melineurine
  • HY-N17416
    ω-Hydroxydigitoemodin 159898-12-1
    ω-Hydroxydigitoemodin is an anthraquinone derivative with anti-acetylcholinesterase activity, found in the marine fungus Trichoderma harzianum XS-20090075.
    ω-Hydroxydigitoemodin
  • HY-N17425
    Lakoochin C 2170152-91-5 98%
    Lakoochin C is an inhibitor of acetylcholinesterase (AChE) (IC50 = 61.86 μM) and butyrylcholinesterase (BChE) (IC50 = 47.21 μM). Lakoochin C may be used in research related to Alzheimer's disease.
    Lakoochin C
  • HY-N17468
    Neocrocin B 2001062-74-2
    Neocrocin B is a carotenoid crocin. Neocrocin B inhibits L-Glutamic acid (HY-14608)-induced neuronal cell damage in a dose-dependent manner. Neocrocin B can be used in studies related to neuronal injury.
    Neocrocin B
  • HY-N17611
    5,6,7-Trihydroxy-4'-methoxyflavone 6563-66-2 98%
    5,6,7-Trihydroxy-4'-methoxyflavone (4'-O-Methylscutellarein) is a flavonoid and a weak inhibitor of xanthine oxidase. 5,6,7-Trihydroxy-4'-methoxyflavone possesses antithrombotic and antioxidant activities. 5,6,7-Trihydroxy-4'-methoxyflavone has an IC50 value of 25.29 µM for DPPH free radical scavenging. 5,6,7-Trihydroxy-4'-methoxyflavone can also inhibit H2O2-induced damage to PC12 cells. 5,6,7-Trihydroxy-4'-methoxyflavone is applicable for the research of diseases such as cerebrovascular disorders.
    5,6,7-Trihydroxy-4'-methoxyflavone
  • HY-N17727
    Divaricatol 331433-08-0 98%
    Divaricatol is an orally ative chromone natural product and an active component in Saposhnikovia divaricata. Divaricatol reduces the release of pro-inflammatory cytokines and restores immune homeostasis by stably binding to 5KIR (a target of the TNF/IL-17 pathway). Divaricatol exerts analgesic effects in mouse models. Divaricatol can be used in the research of pain, diarrhea-predominant irritable bowel syndrome (IBS-D) and qi deficiency syndrome.
    Divaricatol
  • HY-N17764
    Meliasendanin D 4'-O-β-D-glucopyranoside 1931100-79-6
    Meliasendanin D 4'-O-β-D-glucopyranoside (Example 1) is a neolignan-type lignan that may have potential functions in controlling blood sugar, lowering blood pressure, and exhibiting antibacterial, anti-inflammatory, analgesic, or immunomodulatory effects, which require further experimental verification.
    Meliasendanin D 4'-O-β-D-glucopyranoside
  • HY-N17768
    Obtusichromoneside B 2414481-39-1
    Obtusichromoneside B is a novel naphthyl glycoside compound that can be isolated from Cassia obtusifolia seeds. Cassia obtusifolia possesses various physiological functions, including neuroprotection, anti-inflammatory effects, and hepatoprotection.
    Obtusichromoneside B
  • HY-N17770
    Obtusinaphthalenside B 2584414-13-9
    Obtusinaphthalenside B is a novel naphthyl glycoside compound that can be isolated from Cassia obtusifolia seeds. Cassia obtusifolia has physiological functions related to neuroprotection, anti-inflammation, and hepatoprotection.
    Obtusinaphthalenside B
  • HY-N17775
    Scutellarein 4'-methyl ether 7-O-glucuronide 64924-06-7
    Scutellarein 4'-methyl ether 7-O-glucuronide (Clerodendroside) is a flavonoid inhibitor of acetylcholinesterase (AChE) (IC50=1 mg/mL). Scutellarein 4'-methyl ether 7-O-glucuronide can be isolated from Plectranthus barbatus. It also possesses antioxidant activity and can be used in research on neurological diseases such as Alzheimer's disease.
    Scutellarein 4'-methyl ether 7-O-glucuronide
  • HY-N17776
    Diosmetin 6-C-glucoside 15822-82-9
    Diosmetin 6-C-glucoside is a C-glycosyl flavonoid compound that can be isolated from sugarcane bagasse.
    Diosmetin 6-C-glucoside
  • HY-N17784
    Peiioside A 1610618-94-4
    Peiioside A is a phenylethanoid glycoside compound that can be isolated from the leaves and stems of Callicarpa longissima. Callicarpa longissima has traditional medicinal uses for treating colds, coughs, arthritis, and bleeding, and can be used in the research of anti-inflammatory and antibacterial agents, as well as in neuroprotection-related fields.
    Peiioside A
  • HY-N17816
    Tambulin 571-72-2 98%
    Tambulin is an orally active flavonol compound found in Zanthoxylum armatum. Tambulin can inhibit cell proliferation, induce apoptosis and inhibit ROS production. Tambulin upregulates cleaved caspase-3, cleaved caspase-9, and Bax, downregulates Bcl-2 levels. Tambulin can stimulate glucose-dependent insulin secretion and induce endothelium-independent vasorelaxation. Tambulin binds to succinate dehydrogenase (SDH) (Ki = 11.02 μM) and shows significant ferric reducing power. Tambulin can enhances oxidative stress resistance, reduces, lipofuscin deposits, lipid levels, α-synuclein levels, improves locomotary behavior, and dopamine levels in in age-synchronized L1 hermaphrodite Caenorhabditis elegans models of ageing and Parkinson's disease. Tambulin can be used for the researches of Parkinson's disease, lung squamous cell carcinoma, and diabetes.
    Tambulin
  • HY-N17821
    Butrin 492-13-7 98%
    Butrin is a compound found in Butea monosperma flowers. Butrin reduces expression of SIRT1, AURKB, cyclin D1, pAKT, GSK-3β, β-catenin, and TGF-3β expression, enhances apoptosis and ROS production in cancer cells. Butrin downregulates Wnt and NF-κB signaling, mitigates oxidative stress, reduces proinflammatory cytokine (TNF-α, IL-6 and IL-8) production and suppresses neuroinflammation. Butrin inhibits IKK enzyme activity. Butrin can be used for the researches of colorectal cancer, Alzheimer’s disease, and rheumatoid arthritis.
    Butrin
  • HY-N17853
    Siaresinolic acid 511-77-3
    Siaresinolic acid is a compound found in the leaves of Sabicea grisea. Siaresinolic acid shows antinociceptive and anti-inflammatory activity. Siaresinolic acid reduces nociceptive behavior by ATP-dependent potassium channel, inhibits leukocyte influx, plasma leakage, and proinflammatory mediator (TNF-α, IL-1β) production. Siaresinolic acid does not induce cytotoxicity in murine macrophages, alter locomotor activity at high doses. Siaresinolic acid can be used for the research of pleurisy and pain.
    Siaresinolic acid
  • HY-N17920
    6α-Methoxygeniposide 135383-98-1
    6α-Methoxygeniposide is a geniposide-type iridoid compound present in the leaves of Gardenia jasminoides cv. fortuneana HARA. 6α-Methoxygeniposide induces neurite outgrowth in pheochromocytoma cells.
    6α-Methoxygeniposide
  • HY-N17929
    Doliroside A 93078-67-2
    Doliroside A is an Aβ42-binding agent with an IC50 of 26.57 μM for Aβ42. Doliroside A binds to Aβ42 nuclei and oligomers to form stable complexes, suppresses Aβ42 fibrillation, and redirects Aβ42 into off-pathway, amorphous oligomers. Doliroside A can be used for the research of alzheimer’s disease (ad).
    Doliroside A
Cat. No. Product Name / Synonyms Application Reactivity